Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P
Biological objectives and pharmacology regarding curcumin
Publication ChapterAsma El-Magboub Aasialainen kauniita naisia,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the biggest part of the red dye out of turmeric, an enthusiastic Indian spruce that’s obtained from the fresh rhizome of one’s warm bush Curcuma longa, and therefore is one of the Zingiberaceae nearest and dearest. Contained in this section, i talk about the pharmacological factors of curcumin and you will discuss the latest unit basics of these things. I next comment new shown and you can possible health-related uses away from curcumin. Curcumin known typically given that a restorative representative, however, the system of step was outlined. The fresh pharmacological effects of curcumin be seemingly caused by a good synergism of networking sites out of poor biochemical connections having multiple physical targets within the interconnected signaling pathways. These types of goals include enzymes such as cyclooxygenase, lipoxygenase and you can proteins kinases, and you may transcription products such as for instance NF-?B, STAT and Nrf2. Modulation ones molecules affects downstream affectors that make the brand new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and antimicrobial circumstances regarding curcumin. These consequences had been checked-out for the logical samples off curcumin to own soreness and you will inflammatory disease, disease, Alzheimer problem, cardiovascular infection, and diabetes. The newest trials used adjustable dosage off curcuminwith other wavelengths and you will cycle, toward general end one to higher dosage from curcumin from the quantity of g must get healing effects. Read more
Curcumin: Synthesis, Emerging Character in Aches Management and you can Fitness Implications
Publication Section Samples of bush-derived pharmaceuticals with get to be the desire out-of continued and you will rapid browse and you may development attract has actually, thus far, become somewhat scarce. Immediately after a long period, the past 2 decades was in fact described as good 100-bend rise in the amount of medical blogs had written a-year one try out of significance for the entry to curcumin into the biomedicine. Find out more
Structure, synthesis and biological products off curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many prospective pharmacological consequences and could enjoys healing software in lot of condition says, once the discussed in more detail in the earlier section. not, the possibility health-related effectiveness out of curcumin is bound from the its physicochemical qualities regarding worst liquid solubility and you may imbalance, which cause low bioavailability. Prodrugs off curcumin bring an easy way to update of the biopharmaceutical and you can pharmacokinetic services, and could allow exploitation of the pharmacological results of curcumin. Contained in this part, i earliest review the fresh physicochemical and you can pharmacokinetics off curcumin. We upcoming explain the appearance of curcumin prodrugs that have increased h2o solubility and you may enhanced agents balance that may be converted back to 100 % free curcumin through to bioactivation during the vivo. We highlight previous profits of this type, which have a focus on the construction, synthesis and you will research out of prodrugs according to promoieties and proteins, fatty acids, nucleic acids, dicarboxylic acids, and you can polymeric product particularly hyaluronic acidic and you can polyethylene glycol. This section gets the reason for optimisation of one’s physicochemical and you may biopharmaceutical services and the physiological circumstances out-of curcumin prodrugs, into mission playing with of those curcumin types in scientific applications. Read more
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